SANTEN Sante Me-di-cal Plus 12 Eye Drop Made in Japan. In the age of advanced information technology there is an increasing number of environments in which the eyes can become overworked. Such environments lead to declined focus-adjustment function and tired eyes (eye fatigue), manifesting as a heavy feeling in the back of the eyes. Sante 12 is an eye drop for treating eye fatigue that contains a precise balance of twelve active ingredients, four of which are at the maximum concentrations, including vitamin B12 and neostigmine methyl sulfate, which are effective for eye fatigue. Sante 12 improves declined focus-adjustment function by working on the muscles and parasympathetic nerves responsible for adjusting focus, moisturizes dry eyes, and facilitates tissue metabolism by supplying nutrients to the eyes. This product supports a “healthy eye” life for people suffering eye strain due to the demands of modern society. Dosage: Instill 1 to 3 drops at a time, 5 to 6 times daily.